What is the appropriate waiting time between the instillation of different ophthalmic medications?

The appropriate waiting time between the instillation of different ophthalmic medications is generally recommended to be at least 3 minutes. This interval allows for proper absorption of the first medication before introducing the second one, reducing the risk of dilution or interference between the two drugs. If the drops are administered too closely together, the second medication may wash away or not penetrate effectively into the eye, potentially diminishing its therapeutic effect.

While some sources might suggest different waiting periods, 3 minutes is commonly accepted and aligns with guidelines to ensure that each medication can work effectively. This timing helps maintain the efficacy of both medications, particularly when they have different mechanisms of action or when one medication may alter the absorption or effectiveness of another.